VSSC at Thiruvananthapuram is the lead centre for the development of satellite launch vehicles and associated technologies. The centre pursues research and development in the fields of aeronautics; avionics; composites; computer and information; control, guidance and simulation; launch vehicle design; mechanical engineering; mechanisms, vehicle integration and testing; propellants, polymers, chemicals and materials; propulsion, propellants and space ordnance; and systems reliability.

ISAC at Bangalore is engaged in developing satellite technology and implementation of satellite systems for scientific, technological and application missions. ISAC is functionally organised into five major areas: mechanical systems area including structures, thermal systems and spacecraft mechanisms; digital and communications area including digital systems and communication systems; integration and power area comprising spacecraft checkout, systems integration and power systems; controls and mission area consisting of control system, mission development and computer and information; and facilities.

SDSC SHAR, with two launch pads is the main launch centre of ISRO and has facilities for solid propellant processing, static testing of solid motors, launch vehicle integration and launch operations, range operations comprising telemetry, tracking and command network and mission control centre.

LPSC is the lead centre in the development of liquid and cryogenic propulsion for launch vehicles and satellites. LPSC at Thiruvananthapuram carries out design and system engineering of earth storable and cryogenic engine and stages for launch vehicles, design and development of bipropellant thrusters and electric propulsion thrusters for spacecraft, control components and control systems. LPSC at Bangalore carries out design, development and testing of propulsion systems for spacecraft. It also carries out transducer design and development.

SAC at Ahmedabad is engaged in the development of payloads for communication, meteorological and remote sensing satellites. SAC also carries out research and development on various space applications programme. The activities are grouped under microwave systems, satellite communication applications, sensor developments, image and information processing and remote sensing applications.

DECU at Ahmedabad is involved in the conceptualisation, definition, planning, implementation and socio-economic evaluation of space applications.

ISTRAC provides mission support to low-earth orbit satellites as well as launch vehicle missions. ISTRAC activities are organised into network operations, network augmentation, mission operation and spacecraft health monitoring, communications and computers and control centre facilities and development projects. Research and development in the area of radar systems needed for space programme like tracking radars, wind profile radar and weather radars needed for meteorological applications are being undertaken.

MCF at Hassan in Karnataka and Bhopal in Madhya Pradesh monitors and controls all the geo-stationary satellites of ISRO. MCF carries out operations related to initial orbit raising of satellites, in-orbit payload testing, and on-orbit operations throughout the life of these satellites.

IISU at Thiruvananthapuram carries out research and development in inertial sensors and systems and allied satellite elements. IISU is organised into research and development groups in the areas of launch vehicle inertial systems, spacecraft inertial systems, inertial system production and reliability and quality assurance. It has facilities for precision fabrication, assembly, clean room and integration and testing.

LEOS at Bangalore carries out research and development in the field of electro-optic sensors and cameras required for satellites and launch vehicles.

NRSC at Hyderabad is responsible for remote sensing satellite data acquisition and processing, data dissemination, aerial remote sensing and decision support for disaster management.

SCL is entrusted with design and development of Very Large Scale Integration (VLSI) devices and development of systems for telecommunication and space sectors. SCL has facilities for fabrication of micro-electronic devices in 0.8 micron range and Micro Electro Mechanical Systems (MEMS). Actions to upgrade the facilities to fabricate advanced devices in 0.25 micron range have been initiated.